发明名称 |
BCR-ABL DIRECTED COMPOSITIONS AND USES FOR INHIBITING PHILADELPHIA CHROMOSOME STIMULATED CELL GROWTH |
摘要 |
Compositions comprising or encoding one or more peptides that inhibit the Bcr-Abl oncoprotein and that bind to molecules involved in Bcr-Abl function are disclosed. The peptides and polypeptides inhibit the growth of, and induce cell death of, Philadelphia chromosome-positive leukemia cells expressing the Bcr-Abl oncoprotein. Methods for treating leukemias (e.g., CML, ALL and AML), including autologous bone marrow transplant therapy, using the peptide and polypeptide compositions of the invention are also provided.
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申请公布号 |
WO9625520(A1) |
申请公布日期 |
1996.08.22 |
申请号 |
WO1996US02091 |
申请日期 |
1996.02.16 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;ARLINGHAUS, RALPH, B.;LIU, JIAXIN;BERSTEIN-LOPEZ, GABRIEL;LU, DAI |
发明人 |
ARLINGHAUS, RALPH, B.;LIU, JIAXIN;BERSTEIN-LOPEZ, GABRIEL;LU, DAI |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61P31/12;C07K14/82;C12N5/08;C12N15/12;C12P21/02;(IPC1-7):C12Q1/68;C12N15/85;A61K38/08;A61K38/17;C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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