Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protein transferase is indicated. Also disclosed are benzazepines of the following general formula (II) having similar utility as the aforementioned benzodiazepines: <IMAGE> (II)
申请公布号
US5532359(A)
申请公布日期
1996.07.02
申请号
US19940328595
申请日期
1994.10.25
申请人
GENENTECH, INC.;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人
MARSTERS, JR., JAMES C.;BROWN, MICHAEL S.;CROWLEY, CRAIG W.;GOLDSTEIN, JOSEPH L.;JAMES, GUY L.;MCDOWELL, ROBERT S.;OARE, DAVID;RAWSON, THOMAS E.;REYNOLDS, MARK;SOMERS, TODD C.