PRODUCTION OF STYRENE DERIVATIVE

摘要

PURPOSE: To obtain the subject compound by ready operation in high yield without using specific facilities by reacting a substituted oxybenzaldehyde with dibromomethane in the presence of an active chloride and metallic zinc in an organic solvent. CONSTITUTION: A substituted oxybenzaldehyde of formula I (R is an alkyl, an alkoxyalkyl, an alkylcarbonyl, an alkoxycarbonyl, an O-containing 5- to 6-atom heterocyclic ring or alkylsilyl) is reacted with dibromomethane in the presence of an active chloride and metallic zinc in an organic solvent. The aldehyde group is selectively converted into an ethylene group by the reaction to give a substituted oxystyrene derivative of formula II containing a desired substituent oxy group. A nitrogen-containing polar compound is preferable as the organic solvent. Preferably the metallic zinc is preferably pretreated with an active chloride and fed to the reaction. An alkylchlorosilane compound, an acyl chloride compound, anhydrous hydrogen chloride and thionyl chloride are preferable as the active chloride.