Process for the preparation of the (-)-N-methyl-N-(4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl) benzamide and its pharmaceutically acceptable salts

摘要

A process is described for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine of formula (I) and for the preparation of the (-)-N-methyl-N-Ä4-(4-phenyl-4-acetylamino-piperidin-1-yl)-2-(3,4-dichl orophenyl)butylÜ benzamide and of its pharmaceutically acceptable salts using the compound of formula (I) as synthesis intermediate.