发明名称 |
Biocompatability of solid surfaces |
摘要 |
An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylimine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkyaimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
|
申请公布号 |
US5415938(A) |
申请公布日期 |
1995.05.16 |
申请号 |
US19940193964 |
申请日期 |
1994.02.09 |
申请人 |
MEDTRONIC, INC. |
发明人 |
CAHALAN, PATRICK T.;VERHOEVEN, MICHEL;HENDRIKS, MARC;CAHALAN, LINDA |
分类号 |
A61L24/00;A61L33/00;(IPC1-7):A61F2/01 |
主分类号 |
A61L24/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|