Biologically active reagent prepared from aldehyde-containing polymer, test kit, analytical element and methods of use

摘要

A biologically active reagent is prepared by reacting a biologically active substance covalently to a polymeric particle having pendant aldehyde groups. Such groups are provided by a polymerizable monomer represented by the structure: <IMAGE> wherein Ar is arylene, R and R1 are independently hydrogen, halo or lower alkyl, R2 and R3 are independently alkylene of 1 to 4 carbon atoms in the chain, R4 is arylene, m is 0 or 1, and n is an integer of 1 to 4. These reagents can be used in a variety of specific binding and affinity purification methods, and in both solution assays and dry analytical elements.