发明名称 |
Lactol derivatives as inhibiters of cathepsin L. |
摘要 |
The present invention provides novel compound of the formulas (Ia) or (I): <CHEM> wherein Q is one or two amino acid residues which may be substituted; R<3> is a carboxyl group which may be esterified or an acyl group; A is an alkylene group; B is hydrogen or an alkyl group which may be substituted or an acyl group; or a salt thereof; <CHEM> wherein R<1> and R<2> may be the same or different and each is hydrogen or a hydrocarbon residue which may be substituted; R<3>, A and B have the same definitions as those shown above; m and n each is 0 or 1; provided that where both m and n are both equal to 0, R<3> is a carboxyl group which may be esterified or an acyl group having not less than 7 carbon atoms; or a salt thereof. The compound (Ia) or (I) shows cathepsin L inhibitory and bone resorption inhibitory activities and are useful as a prophylactic/therapeutic agent for osteoporosis. |
申请公布号 |
EP0641800(A1) |
申请公布日期 |
1995.03.08 |
申请号 |
EP19940113669 |
申请日期 |
1994.09.01 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
SOHDA, TAKASHI;FUJISAWA, YUKIO;OI, SATORU;MIZOGUCHI, JUNJI |
分类号 |
A61K38/00;C07K5/06;C07K5/078 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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