Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents

摘要

This invention relates to unsymmetrical mono-3-nitro bis-naphthalimides of formula <IMAGE> including (R,R)-2-{2-[2-((2-(1,3-dioxo-1H-benz[de]isoquinolin-2-(3H)-yl)-propyla mino))ethylamino]-1-methylethyl}-5-nitro-1H-benz[de]isoquinolin-1,3-(2 H)-dione, processes for their preparation, pharmaceutical compositions containing them, and methods of using them to treat cancer, particularly solid tumor carcinomas, in mammals.