发明名称 |
Chemically modified allergens and process for the preparation thereof |
摘要 |
Chemically modified allergens, whose allergenic activity is reduced with respect to that of the corresponding native allergenic material, which are capable of inducing specific antibodies addressed towards said native allergenic material, wherein a portion of the primary amino groups of the protein molecule of the native allergen are chemically modified so as to give simple or substituted carbamylic amino groups, or substituted thiocarbamylic amino groups, or possibly substituted guanidino groups, and process for the production thereof. The allergens so modified are not polymerized with each other, they are soluble in water media, they are resistent to tryptic hydrolysis and they show particularly suitable for being administered in hyposensitizing therapeutic treatments.
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申请公布号 |
US5354848(A) |
申请公布日期 |
1994.10.11 |
申请号 |
US19900588344 |
申请日期 |
1990.09.26 |
申请人 |
LABORATORIO FARMACEUTICO LOFARMA S.R.L. |
发明人 |
FALAGIANI, PAOLO;BRENNA, ORESTE;MISTRELLO, GIOVANNI |
分类号 |
A61K39/35;A61K39/36;A61P37/08;C07K1/113;C07K14/00;C07K14/41;C07K14/415;C07K14/76;(IPC1-7):A61K39/35;C07K3/08 |
主分类号 |
A61K39/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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