| 摘要 |
<p>PURPOSE:To readily and inexpensively obtain a compound by oxidizing a 2- alkyloxy-3,3,3-trifluoro-1-propanol with nitric acid containing copper. CONSTITUTION:A compound of the formula (R is methyl which may have a substituent), especially an optically active compound having an asymmetric center on the methine carbon bound to the trifluoromethyl group and the alkyloxy group is reacted with an oxidizing agent comprising nitric acid containing a catalytic amount, especially 1-10mol.%, of copper at 0 deg.C to the boiling temperature of a solvent to produce the compound. The compound is useful as a raw material for physiologically active substances such as medicines and agricultural chemicals and for functional organic compounds such as liquid crystals and surfactants, or as an optical resolving agent. Difficultly available 2-methoxy-3,3,3-trifluoropropionic acid, especially its optically active isomer, is readily available. Fluorine-containing organic compounds using the compound as a raw material and having difficultly been synthesized can therefore be produced and organic compounds can optically be resolved with the reagent.</p> |
