CHIRAL ARYLPROPIONATES AND THEIR USE

摘要

Compounds having the formula: Ar-CHOR<1>-CHHal-COOR<2> are useful as chiral synthons, for example in the synthesis of the anti-hypertensive agent diltiazem, and related calcium channel blocking agents. The synthons can be prepared in enantiomerically-purified form without wastage of the unwanted enantiomer.