NEW OLIGOPEPTIDES WITH AFFINITY TO OPIOID RECEPTORS

摘要

2149899 9412532 PCTABS00032 Disclosed are novel oligopeptides with opioid receptor affinity which are straight or cyclic pentapeptides with the primary sequence backbone Tyr-X-Phe-Leu-Z, where X and Z denote amino acids or amino acid derivatives and/or analogues and where X and Z can be covalently coupled to provide a heterocyclic structure wherein Z is chosen among Cys, Glu, Gln or amino derivatives of Glu and Gln; X will be chosen among the amino acids or amino acid analogues Ser, Gly, Pro, AMCA, D-Ala, D- or L-ornithine, D- or L-2,4-diaminobutyric acid, D- or L-Lys and D- or L-Cys. Also disclosed are pharmaceutical preparations comprising said oligopeptides, which are potentially useful as analgesics for alleviating pain, for the treatment of depressions and for increasing the comfort of individuals suffering from extraordinary stress or shock.