发明名称 |
Antiarrhythmic and cardioprotective substituted -1(2H)Isoquinolines, process for their production, medicament containing them and their use for the production of a medicament for combating heart failures. |
摘要 |
Described are guanidinocarbonyl isoquinolines I, <CHEM> with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G <CHEM> X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.
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申请公布号 |
EP0590455(A1) |
申请公布日期 |
1994.04.06 |
申请号 |
EP19930115081 |
申请日期 |
1993.09.20 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
LAL, BANSI, DR.;GIDWANI, RAMESH MATIORAM, DR.;RAJAGOPALAN, RAMANUJAM;PANICKER, RADHA;SANKAR, CHINNAKULANDAI;LANG, HANS-JOCHEN, DR.;ENGLERT, HEINRICH, DR.;SCHOLZ, WOLFGANG, DR. |
分类号 |
A61K31/47;A61K31/472;A61P9/00;A61P9/04;A61P9/06;A61P9/10;C07D217/26;C07D401/04;C07D401/12;C07D413/04;C07D413/12;(IPC1-7):C07D217/26 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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地址 |
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