Method for producing synthetic N-linked glycoconjugates

摘要

A method is disclosed for derivatizing oligosaccharides to form synthetic N-linked glycoconjugates by converting a glycosylamine derivative of the oligosaccharide to a haloacetylated derivative as an intermediate compound prior to formation of the synthetic N-linked glycoconjugate to thereby directly maintain the (beta)-anomeric configuration of said N-linked glycoconjugate.