BINDING COMPETENT OLIGOMERS CONTAINING 2', 5' LINKAGES

摘要

The invention relates to novel modified oligonucleotides, the construction thereof, and their use in oligonucleotide-based therapies. More specifically, the invention is to novel oligomers having 2', 5' linkages between adjacent nucleomonomers which are resistant to nucleases, having enhanced ability to penetrate cells, and which are capable of binding target oligonucleotide sequences in vitro and in vivo. The oligomers of the invention are particularly useful in oligomer-based therapies utilizing the invention oligomers to modulate protein synthesis or transcription or to otherwise inactivate messenger RNA or double stranded DNA.