| 摘要 |
<p>A method is provided for synthesizing cholesta-5,7-diene,3β,25-diol and analogs thereof. A Diels-Alder adduct of a steroid containing a 5,7-diene and a Δ24 double bond is reacted with an oxidizing agent to provide a 24,25-oxido moiety, followed by treatment with a reducing agent effective to cleave the adduct and convert the 24,25-oxido moiety to a 25-hydroxy group. Novel compounds which are Diels-Alder adducts of 5,7-diene-containing steroids and contain a 24,25-oxido group are also provided.</p> |
