| 摘要 |
PURPOSE:To selectively produce an important subject compound as a physiologically active substance and its intermediate in a simple operation and good yield by reacting an olefin with an oxidizing agent in the presence of water using a ruthenium compound as a catalyst. CONSTITUTION:An olefin compound of formula I (R is alkyl, aryl or alkoxycarbonyl; R<2> and R<3> are H, alkyl or aryl and R<1> and R<2> are not simultaneously H and R<1> and R<2>, R<1> and R<3> and R<2> and R<3> may form a ring and R<1> and R<2> and R<2> and R<3> simultaneously may form rings) is oxidized with an oxidizing agent in the presence of water using a ruthenium compound, especially a compound of formula III X is halogen, acyloxy of R<4>COO (R<4> is alkyl) or acetylacetonate], particularly a ruthenium complex, a ruthenium metal, etc., as a catalyst to provide the objective (alpha-hydroxyketone of formula II. This method is industrially advantageous. |
