| 摘要 |
Process for obtaining esters of 1,1-dioxopenicillanic acid and their pharmaceutically acceptable salts of formula 1 <IMAGE> in which R represents an aromatic or heteroaromatic ring, which may or may not be substituted by lower alkyl, hydroxyl, lower alkoxyl, carboxyl and/or aryl groups which in turn may or may not be substituted by halogen atoms or a lower alkyl residue or an aryl or heteroaryl group which may or may not be substituted by hydroxyl residues or halogen atoms, and R2 represents a hydrogen atom or a lower alkoxyl, aryloxy, amine, carboxyl group or group of the type -COOR3 where R3 represents a phenyl or cyclopentophenyl group. They are obtained by reacting compound II, where X represents a bromine atom, with a reducing metal in powder form in aqueous/organic medium. They are useful in the treatment of bacterial infections.
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