发明名称 |
Assessment of bone fragility and prediction of osteoporotic fracture risk using a quantitative determination of circulating under-carboxylated osteocalcin. |
摘要 |
<p>The invention relates to a method for the assessment of bone fragility and osteoporosis fracture risk characterised by : measuring in vitro the concentration of under-carboxylated osteocalcin in a biological fluid sample such as serum, plasma or urine ; comparing the concentration of under-carboxylated osteocalcin in the test sample with the concentration in a control sample containing levels of under-carboxylated osteocalcin representative of the upper limit of the normal range, concentrations above this upper limit being indicative of increased risk of bone fracture. t</p> |
申请公布号 |
EP0557663(A1) |
申请公布日期 |
1993.09.01 |
申请号 |
EP19920400517 |
申请日期 |
1992.02.27 |
申请人 |
DELMAS, PIERRE, DR.;CENTRE DE RECHERCHES EN RHUMATOLOGIE |
发明人 |
DELMAS, PIERRE |
分类号 |
C07K19/00;C07K1/113;C07K14/00;C07K16/00;C07K16/18;C07K16/44;C12N15/02;C12P21/08;C12R1/91;G01N33/53;G01N33/577;G01N33/68 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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