| 摘要 |
<p>Prolamine fractions of grain proteins, applied in weight ratios of 5 to 100 % relative to the active agent being coated, effectively prevent the partitioning of water-soluble or water-insoluble drugs at neutral pH's in the mouth and thereby mask the taste of orally-administered drugs, which normally have a bitter taste, without sacrificing bioavailability. Zein, gliadin or a mixture thereof, particularly in combination with between 2.5 and 15 % of water-insoluble vegetable source oil or wax capable of plasticizing the prolamine fraction, when applied to particles, granules, tablets or other forms of drugs or nutritionals, to an effective thickness of about 1 to about 35 micrometers, in order to encapsulate and prevent release of an orally-administered pharmaceutical or nutritional in a suspension or chewable dosage form until such medicament reaches the stomach.</p> |
