Novel quinolone carboxylic acid derivatives and processes for preparing same.

摘要

The present invention relates to certain novel quinolone compounds of the present invention can be represented by the following formula(I) and novel processes for preparing same. wherein: X is a nitrogen atom or a CH, C-halogen or C-methoxy group; R1 is an optionally substituted C1-7 alkyl group, an optionally substituted C3-7 cycloalkyl group, an optionally substituted alkenyl group, an optionally substituted aryl group or a divalent group of -CH2CH2*CH(CH3)-, -OCH2*CH(CH3)-or -SCH2*CH(CH3)- which forms a ring together with the nitrogen atom to which R1 is attached and with X wherein X is CH; R2 is a hydrogen atom, a carboxy protecting group or a pharmaceutically acceptable metal or organic cation; R3 is -CO2H or (CH2)m-Y, wherein m is 0 or 1 and Y is a hydroxy group, a C1-4 alkoxy group, a C1-4 alkoxycarbonyl group(wherein m is 0) or an amino group optionally substituted with one or two C1-4 alkyl radicals, with one C1-4 alkanoyl radical or with one nitrogen protecting radical metabolizable in vivo, and the carbon atom to which R3 is attached is a chiral carbon atom having the stereochemical configuration of (R), (S) or a mixture thereof; Z is a hydrogen, chlorine or fluorine atom, a hydroxy group, a methyl group or an optionally substituted amino group; and n is 1 or 2. a