| 摘要 |
<p>Pemphigus vulgaris (PV) is a life-threatening skin disease in which autoantibodies against a keratinocyte cell surface 130-kD glycoprotein, PV antigen (PVA), cause loss of cell-to-cell adhesion with resultant epidermal blisters. The present invention relates to DNA sequences encoding the entire amino acid sequence of PVA. The invention also relates to recombinant constructs containing the DNA sequence for PVA, and host cells transformed therewith. In addition, the invention relates to methods of diagnosing and treating persons afflicted with PV disease.</p> |
