发明名称 Kit for preparation of rhenium therapeutic agents for bone cancer without purification
摘要 The process of the present invention includes preparing a first aqueous solution of rhenium in the form of radioactive perrhenate, wherein the concentration of rhenium in said solution is within the range of about 5x10-6M to about 2x10-3M, and then reducing and complexing the radioactive perrhenate by mixing a second solution or lyophilized solid with the first solution. The second solution or lyophilized solid comprises a ligand which complexes with the radioactive perrhenate and a reductant wherein the reductant is present in the second solution at a concentration in the range of about 0.005M to about 0.020M and the ligand is present in the second solution at a concentration in the range of about 0.01M and about 0.15M. The pH of the resultant solution is within the range of about 1.5 to about 5.5.
申请公布号 US5192526(A) 申请公布日期 1993.03.09
申请号 US19910673000 申请日期 1991.03.21
申请人 MALLINCKRODT MEDICAL, INC. 发明人 PIPES, DAVID W.
分类号 A61K51/04;C07B59/00 主分类号 A61K51/04
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