Phophorus-containing HMG-COA reductase inhibitors.

摘要

Novel phosphorus-containing compounds which inhibit the activity of HMG-CoA reductase, are provided. Pharmaceutical compositions and methods of use for the treatment or prevention of hypercholesterolemia, atheroschlerosis, hyperlipoproteinaemia and hyperlipidemia are provided. Compounds are of formula (I): where X is -(CH2)a-, -CH=CH-, C IDENTICAL C-, or -CH2O- (where either -CH2- or -O- is attached to Z) and "a" is 1, 2, or 3; R is hydrogen or lower alkyl; Z is l