发明名称 |
SEQUENCE-SPECIFIC BINDING POLYMERS FOR DUPLEX NUCLEIC ACIDS |
摘要 |
The present invention describes a polymer composition effective to bind in a sequence-specific manner to a target sequence of a duplex polynucleotide at least two different-oriented Watson/Crick base-pairs at selected positions in the target sequence. The composition includes an uncharged backbone with 5- or 6-membered cyclic backbone structures and selected bases attached to the backbone structures effective to hydrogen bond specifically with different oriented base-pairs in the target sequence. Also disclosed are subunits useful for the construction of the polymer composition. The present invention also includes methods for (i) coupling a first free or polymer-terminal subunit, and (ii) isolating, from a liquid sample, a target duplex nucleic acid fragment having a selected sequence of base-pairs. |
申请公布号 |
WO9300352(A1) |
申请公布日期 |
1993.01.07 |
申请号 |
WO1992US05208 |
申请日期 |
1992.06.18 |
申请人 |
ANTI-GENE DEVELOPMENT GROUP |
发明人 |
SUMMERTON, JAMES, E.;WELLER, DWIGHT, D. |
分类号 |
C07H21/04;A61K47/48;C07H21/00;C12N15/00;C12Q1/68 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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