VITAMIN-CONTAINING GRANULES AND PRODUCTION THEREOF

摘要

24205-689 A vitamin-containing granule substantially comprising one or more compounds selected from the group consisting of vitamin B6, vitamin B2, nicotinamide and a pantothenic acid salt and a binding agent, said compound or compounds accounting for 90 to 99 weight % of the granules on the dry basis can be prepared by spray-coating the powders of said compound or compounds with a solution containing a binder while maintaining the powders in the fluidized state in a fluidized-bed granulation apparatus. The granules are highly flowable and blend well with other medicaments, granules, additives, and so on. In addition to this, the granules have excellent compressibility so that they can be processed into tablets with small amounts of excipients and the tablets therefrom have satisfactory high hardness.