| 摘要 |
<p>A novel thiazole derivative represented by general formula (I), which has a selective agonistic activity for 5-HT3 receptor, a pharmaceutical composition thereof, and a process for producing the same. In the said formula, R1 represents hydrogen or lower alkoxy; R?2 and R3¿ are such that R2 represents hydrogen and R3 represents a group, -Y-Het, wherein Y represents a single bond or lower alkylene and Het represents a nitrogenous heterocyclic group, or alternatively R?2 and R3¿ are combined together to form a group, -(CH¿2?)m-NR?4-(CH¿2)n-, wherein m and n are each 1 or 2 and R4 represents lower alkyl; and X represents -NH-, -NHC(=O)NH-, -C(=O)NH- or -NHC(=O)-.</p> |
