发明名称 |
Immunostimulating guanosine derivatives and their pharmaceutical compositions |
摘要 |
7,8-Disubstituted guanosine nucleoside derivatives are found to be potent immune response enhancing agents in human and animal cells. 7-Substituents are heteroatom-substituted-hydrocarbyl radicals having a length greater than ethyl and less than about decyl. 8-Substituents are =O, =S, =Se and =NCN. Compositions and methods of use are also disclosed.
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申请公布号 |
US5093318(A) |
申请公布日期 |
1992.03.03 |
申请号 |
US19880190694 |
申请日期 |
1988.05.05 |
申请人 |
SCRIPPS CLINIC AND RESEARCH FOUNDATION |
发明人 |
GOODMAN, MICHAEL G.;CHEN, ROBERT |
分类号 |
C07D473/18;A61K31/52;A61K31/522;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7076;A61K31/708;A61K39/39;A61P9/04;A61P37/04;C07H19/16 |
主分类号 |
C07D473/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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