| 摘要 |
Oxazolyl derivatives of formula (I), wherein -A<1>=A<2>-A<3>=A<4>- represents a bivalent radical having the formula -CH=CH-CH=CH- (a-1), -N=CH-CH=CH- (a-2), -CH=N-CH=CH- (a-3), -CH=CH-N=CH- (a-4), -CH=CH-CH=N- (a-5), -N=CH-N=CH- (a-6) or -CH=N-CH=N- (a-7); R represents hydrogen or C1-4alkyl; R<1> represents hydrogen, C1-6alkyl or hydroxy-C1-6alkyl; m represents 1 or 2; D represents C1-4alkanediyl; B represents NR<2>, CH2, O, S, SO or SO2 wherein R<2> is hydrogen or C1-4alkyl; n represents 0, 1 or 2; L represents hydrogen; C1-12alkyl; C3-6cycloalkyl; C3-6alkenyl optionally substituted with aryl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; arylcarbonyl; arylC1-6 alkyloxycarbonyl; or a radical of formula -Alk-R<3> (b-1); -Alk-Y-R<4> (b-2); -Alk-Z<1>-C(=X)-Z<2>-R<5> (b-3); or -CH2-CHOH-CH2-O-R<6> (b-4), the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof have antiallergic properties. Compositions containing the same and methods of treating warm-blooded animals suffering from allergic diseases. |
