| 摘要 |
A new group of cyclic peptide derivatives, the A54145 cyclic peptide derivatives, which have the general formula: (R,R2)TrpGlu(HO)Asn 1 +TR <IMAGE> wherein: R is C8-C18-alkyl, optionally substituted C8-C18-alkanoyl or C8-C18-alkenoyl; (R,R2)-Trp represents a group of formula <IMAGE> (Lys-R1) represents -NH(CH2)4CH(NHR1)CO-; R1 is hydrogen or an amino-protecting group; and R2 is hydrogen; or R and R2, taken together, represent a C8-C18-alkylidene group; X is Ile or Val; and Y is Glu or 3-MG; provided that: 1) when R1=H, X=Ile and Y=Glu or 3-MG, R cannot be 8-methylnonanoyl, 8-methyldecanoyl or n-decanoyl; 2) when R1=H, X=Val and Y=3-MG, R cannot be 8-methyldecanoyl; and 3) when R1=H, X=Val and Y=Glu, R cannot be 8-methylnonanoyl; and 4) when R1 is an amino protecting group, R cannot be 8-methylnonanoyl, 8-methyldecanoyl, or n-decanoyl; and their salts are antibacterial agents or intermediates to such agents. Formula 1 compounds wherein R2 is hydrogen improve growth perforamnce in animals; thus, feed compositions for promoting growth in animals such as poultry and methods for increasing growth in animals using these compositions, are also provided.
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