| 摘要 |
(A) To inhibit growth of a target cell in a host there are administered (a) at least one biologically active, ion channel-forming amphiphilic peptide and/or protein, and (b) a toxic anion. A compsn. comprises (a9 and (b). (B) To test an unknown sample for the presence of ion channel-forming peptides, a first portion of the sample is contacted with a first sample of target cells and the biological activity is measured against the cells; a second portion of the sample and a . given amount of fluoride ion are contacted with a second sample of target cells contg. the same type of cells as the first sample, and the biological activity of the second portion and the fluoride ion is measured against the cells; and the two measured activities are compared to determine the presence of channel-forming peptides in the sample. If the second portion has greater biological activity against the target cells than does the first portion, then the sample contains ion channel-forming peptides or proteins. Pref. the target cell is a bacterium. |
