| 摘要 |
PURPOSE:To obtain the subject pharmaceutical, composed of a powdery composition composed of a dialytic solid electrolyte and liquid acid and a powdery composition composed of sodium hydrogencarbonate and glucose, excellent in transportation and preservation of its initial quality and good in maintenance and stability of homogeneity in producing powder. CONSTITUTION:A pharmaceutical obtained by combining (A) the first composition prepared by granulating sodium chloride powder in a fluidized bed while spraying an aqueous solution of respective ingredients of a dialytic solid electrolyte other than the sodium chloride on the sodium chloride powder or mixing the respective ingredients of the dialytic solid electrolyte, pulverizing the resultant mixture, then granulating the obtained powder and blending a liquid acid (preferably acetic acid) with the formed granulated substance with (B) the second composition obtained by mixing powder of glucose with sodium hydrogencarbonate and subsequently granulating the formed mixture. The concentrations of the respective ingredients (A) and (B) are within the ranges shown in Tables 1 and 2 when dissolved in a prescribed amount of water and the respective ingredients are placed in a moistureproof packaging material having <=2.0m<2>.24hr moisture permeability (at 20 deg.C) and then contained together with a drying agent, such as a moisture absorbent, therein. |
