| 摘要 |
The present invention concerns the application of compounds having formula (I), wherein B is such that R-NH-B is an aminobenzoic acid-derived anesthetic: wherein R represents H or an alkyl C1-C5 radical, preferably linear, possibly functionalized in position 2 to 5; wherein AAn is an oligopeptide group consisting of 1 to 10 alpha amino acids, preferably 2 to 6, i.e. in which n is a whole number from 1 to 10 and AA represents natural amino acids or synthetic alpha amino acids in the form of D or or D, L, whereby said alpha amino acids in the form of D or L or D,L, whereby said alpha amino acids may be different, bearing in mind that when R-NH-B represents benzocaine, the first C-terminal acid is L phenylalanine when n = 1 and L, D or D,L pehnylalanine when n is greater than 1 and their pharmaceutically acceptable salts, to the preparation of pharmaceutical compositions useful as anesthetics. The invention also concerns compounds for anesthetic use and a process for increasing the potency of anesthetics having an aromatic amine group. |
