| 发明名称 |
Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor |
| 摘要 |
A modified tissue plasminogen activator having an improved in vivo half-life characterized in that the normal protein moiety of 527 amino acids is mutated at the site Cys73->Arg.
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| 申请公布号 |
US4963357(A) |
申请公布日期 |
1990.10.16 |
| 申请号 |
US19880149793 |
申请日期 |
1988.01.29 |
| 申请人 |
MONSANTO COMPANY |
发明人 |
BELL, LESLIE D.;MAYER, ERNEST J.;PALMIER, MARK O.;TOLUNAY, H. ESER;WARREN, THOMAS G.;WUN, TZE-CHEIN |
| 分类号 |
A61K38/00;C12N9/72;C12N15/58 |
主分类号 |
A61K38/00 |
| 代理机构 |
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