| 摘要 |
PURPOSE:To provide the subject compound useful as an intermediate for fine chemicals and as a raw material for drugs, etc., in high yield and purity by reacting resorcinol with acetic anhydride in acetic acid solvent to give resorcinol monoacetate and subsequently subjecting the product to a transfer reaction in the presence of a zinc dihalide. CONSTITUTION:Resorcinol is reacted with acetic anhydride in an amount of approximately 0.2-1mol per mol of the resorcinol at approximately 30-100 deg.C, preferably 40-80 deg.C, in acetic acid solvent to give resorcinol monoacetate, which is subjected to a transfer reaction in the presence of a zinc dihalide, preferably zinc dichloride, in an amount of approximately 0.2-1mol per mol of the resorcinol at approximately 90-140 deg.C, preferably approximately 100-130 deg.C, to provide substantially colorless 2,4-dihydroxyacetophenone useful as a raw material for photosensitive materials, perfumes, resins, etc., and having a high quality in a high yield, particularly without requiring any tedious operation such as distillation or crystallization after the reaction. |
