| 发明名称 |
RENIN INHIBITING PEPTIDES WITH POLAR END GROUPS |
| 摘要 |
The present invention provides novel renin-inhibiting peptides having a noncleavable transition state insert corresponding to the 10,11- position of the renin substrate (angiotensinogen) and a polyhydroxy-substituted alkyl moiety bonded directly through carbon or nitrogen to the N-terminus. Such inhibitors are useful for the diagnosis and control of renin-dependent hypertension and other related diseases. |
| 申请公布号 |
ZA8900723(B) |
申请公布日期 |
1989.10.25 |
| 申请号 |
ZA19890000723 |
申请日期 |
1989.01.30 |
| 申请人 |
THE UPJOHN COMPANY |
发明人 |
GORDON L. BUNDY;SUVIT THAISRIVONGS;NORMAN A. NELSON;JACKSON B. HESTER JR;JED F. FISHER;MICHAEL F. LIPTON |
| 分类号 |
C07D263/06;A61K38/55;A61P9/12;C07C271/48;C07D493/08;C07F7/18;C07K5/02;C07K5/08;C07K5/10;C07K9/00;C07K14/81 |
主分类号 |
C07D263/06 |
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