Process for the preparation of cyclopentadec-4-ynone and of its 3-methyl homologue

摘要

The macrocyclic acetylenic ketones of formula <IMAGE> (I) wherein symbol R designates a hydrogen atom or a methyl radical are prepared by an anodic oxidation of a hydrazone of formula <IMAGE> (II) wherein R has the above given meaning and A represents a hydrogen atom or a sulfonyl radical of formula R1-SO2-, wherein R1 stands for a substituted or unsubstituted aryl group. Compounds (I) are useful industrial intermediates for the preparation of EXALTONE TM and muscone, two musk ingredients widely used in the perfume industry.