A PROCESS FOR PRODUCING A HEPATITIS B INFECTION PREVENTING VACCINE

摘要

A process for producing a hepatitis B infection preventing vaccine containing hepatitis B surface antigen as a main component thereof which comprises removing human plasma components possibly causing adverse effects and components capable of causing hepatitis B infection by incorporating steps of fractionation using ammonium sulfate, adsorption on a colloidal silicate and fractionation using polyethylene glycol into the purification stage after heat treatment and further carrying out a treatment for infectivity inactivation without causing any antigenicity impairment.