Substituted hydantoin compounds.

摘要

The present invention is concerned with compounds of formula (I) <CHEM> wherein Z is C5-12 straight or branched alkyl, C3-12 alkenyl or alkynyl, C6 or C10 aryl, C6 or C10 aryl-C1-12 alkyl (wherein in either case the aryl group is optionally substituted by one or more groups independently selected from phenyl, C1-4 alkyl, C1-4 alkoxy, nitro, and halo) or C4-8 cycloalkyl-C1-12 alkyl; Z<1> is a group of formula -CH2-X-X<1>-X<2>, wherein X is selected from -(CH2)2-and cis and trans -CH=CH-, X<1> is a covalent bond or a straight or branched alkylene chain having from 1 to 6 carbon atoms optionally having one of its methylene groups replaced by oxa (-O-) or this (-S-) provided that at least one carbon atom separates the oxa or thia group from a carboxyl or -CH=CH-group, and X<2> is a carboxyl group, a C1-4 alkyl ester, or an amide group; Z<2> is a group selected from -NH-CH2-R and -N=CH=R, wherein R is a group selected from -CO-Y and -CH(Y<1>)-Y, Y being a group selected from C3-8 alkyl, C3-8 alkenyl, phenyl-C1-4 alkyl and phenyl (wherein the phenyl group in both cases is optimally substituted by one or more groups independently selected from C1-4 alkyl, C1-4 alkoxy, nitro, halo and trihalomethyl), C4-8 cycloalkyl, and 5- or 6-membered heterocyclic radicals containing at least one heteroatom selected from oxygen, sulphur and nitrogen; and Y<1> being a group selected from hydrogen, hydroxy, C1-4 alkoxy and C2-5 acyloxy; and salts and solvates thereof.