Cyanoguanidine derivative and process for preparation thereof.

摘要

Cyanoguanidine derivatives of formula (I) wherein R is lower alkyl and R' is hydrogen or a lower alkyl are precursors for the synthesis of N-cyano-N'-methyl-N''-[2-{(5-methyl-1H-imidazol-4-yl)methylthio]ethyl]-HY # guanidine (cimetidine) or homologues thereof. These cyanoguanidine derivatives are prepared by reacting a haloketone derivative with an ammonium salt and a lower alkanoic acid salt or by reacting another cyanoguanidine derivative with an ammonium salt.