Pancreatic secretory trypsin inhibitor and its variants produced by genetic engineering.

摘要

A peptide which essentially has the amino acid sequence of pancreatic secretory trypsin inhibitor (PSTI) and variants of this peptide in which one or more of the amino acids of the original sequence are replaced by other amino acids are described. These peptides are modified in an advantageous manner with respect to the specificity of their inhibitor action. A process for the preparation of the peptides and their pharmaceutical use is additionally described.