SYSTEM AND METHOD FOR JOINT ESTIMATION OF ATTENUATION AND ACTIVITY INFORMATION

摘要

Imaging system and method are presented. Emission scan (ES) and anatomical scan (AS) data corresponding to a target volume in a subject are received. One or more at least partial AS images are reconstructed using AS data. An image-space certainty (IC) map representing a confidence level (CL) for attenuation coefficients of selected voxels in AS images and a preliminary attenuation (PA) map based on AS images are generated. One or more of selected attenuation factors (AF) in projection-space are initialized based on PA map. A projection-space certainty (PC) map representing CL for the selected AF is generated based on IC map. An emission image of the target volume is initialized. The selected AF and emission image are iteratively updated based on the ES data, PC map, initial AF, and/or initial emission image. A desired emission image and/or AF values are determined based on the iteratively updated AF and/or emission image.

主权项

1. A method for imaging a subject, comprising:
receiving emission scan data and anatomical scan data corresponding to the target volume in the subject; reconstructing one or more at least partial anatomical scan images using the anatomical scan data; generating an image-space certainty map that represents a level of confidence corresponding to an attenuation coefficient for one or more selected voxels in the one or more at least partial anatomical scan images; generating a preliminary attenuation map based on the one or more at least partial anatomical scan images; initializing one or more of a selected set of attenuation factors in a projection-space corresponding to the emission scan data based on the preliminary attenuation map; generating a projection-space certainty map corresponding to the emission scan data that represents a level of confidence corresponding to a value of one or more of the selected set of attenuation factors based on the image-space certainty map; initializing an emission image corresponding to the target volume in the subject; iteratively updating one or more of the selected set of attenuation factors and the emission image based on the emission scan data, the projection-space certainty map, the initial attenuation factors, the initial emission image, or combinations thereof; and determining a desired emission image, desired values of the attenuation factors, or a combination thereof, based on the iteratively updated attenuation factors and the iteratively updated emission image.