| 摘要 |
There are disclosed compounds of the formula <IMAGE> wherein R1 and R2 are each, independently, hydrogen or lower alkyl, or R1 and R2 taken together represent <IMAGE> <IMAGE> <IMAGE> <IMAGE> +TR <IMAGE> A is O or NR3; B is -(CH2)n-, <IMAGE> R3 is hydrogen or lower alkyl; R4 is hydrogen, lower alkyl, aryl of 6-12 carbon atoms or halo; R5 is unsubstituted or substituted phenyl, 2-pyridinyl, 2-pyrimidinyl, 2-pyrazinyl or 3-pyridazinyl, where the substituents are selected from the group lower alkyl, lower alkoxy, halo, cyano, nitro and trifluoromethyl; Z is -(CH2)n- or vinylene; X is lower alkylene, vinylene or O; m is 2-5; n is 1-3; o is 1-5; and the pharmaceutically acceptable salts thereof and their use as antipsychotic/anxiolytic agents having a low liability for extrapyramidal side effects.
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