PROCESS FOR PRODUCTION OF SPERGUALIN DERIVATIVES CONSOSTING OF NEW PHENILENE GROUP AND FOR PRODUCTION OF MEDICAL PREPARATIVES CONSISTING OF SUCH COMPOUNDS

摘要

The present invention reales to novel Spergualin related compounds, and a process for producing the same. More particularly, the invention reales to Spergualin related compounds of the formula: …… wherein R1 is a lower alkylene group which may be substituted by a hydroxymethyl group; X is a hydrogen atom or a halogen alom; m and n are each 0 or an integer of 1 to 5, and salts thereof, as well as a process for producing the compounds of formula (I) and salts thereof by removing the protecting groups from a protected Spergualin related compounds of the formula: …… wherein R1 is a straight chain or branched lower alkylene group which may be substituted by a hydroxymethyl group, the hydroxyl group of which may be protected; R2 is an amino protecting group; R3 is a protected amino group; X, m and n are as defined above. …The compounds of the formula I have anti-tumor activity and can therefore be used as medicaments.