发明名称 |
DRUG PREPARATION OF BACILLUS NATTO |
摘要 |
PURPOSE:To obtain a drug preparation produced from Bacillus natto and having antitumor activity, by culturing Bacillus natto in a medium containing water- extract of soybean or contacting Bacillus natto with an antibiotic substance or heating Bacillus natto at a temperature above a protein-denaturation temperature and using the obtained cells of Bacillus natto as active component. CONSTITUTION:Bacillus natto [bacterial strain used in the production of NATTO (fermented soybean)] is cultured in a soybean extraction liquid produced by extracting soybean with hot water at about >=90 deg.C and the bacterial cells are collected from the culture product. The cells are suspended in a liquid medium such as Bernheimer base medium, added with sufficient amount of an antibiotic substance having beta-lactam ring (e.g. penicillin or cephalosporin antibiotic substance) and maintained for a short time. As an alternative method, the bacterial cells or a suspension of cells are heated at 70-100 deg.C (i.e. above the protein-denaturation temperature) for 10 - several tens min and the treated cells are collected. |
申请公布号 |
JPS62190091(A) |
申请公布日期 |
1987.08.20 |
申请号 |
JP19860032343 |
申请日期 |
1986.02.16 |
申请人 |
KAMEDA YUKIO;KAMEDA YUKIAKI |
发明人 |
KAMEDA YUKIO;KAMEDA YUKIAKI |
分类号 |
C12N1/20;C12P1/04;C12R1/07;C12R1/125 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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