| 摘要 |
Compounds of formula (I), and pharmaceutically acceptable salts thereof: <IMAGE> (I) wherein L is NH or O; X is a moiety capable of hydrogen bonding to the NH group depicted in formula (I); R1 and R2 are independently selected from hydrogen, halogen, CF3, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-7 acyl, C1-7 acylamino, C1-6 alkylsulphonylamino, N-(C1-6 alkylsulphonyl)-N-C1-4 alkylamino, C1-6 alkylsulphinyl, carboxy, C1-6 alkoxycarbonyl, hydroxy, nitro or amino, aminocarbonyl, aminosulphonyl, aminosulphonylamino or N-(aminosulphonyl)-C1-4 alkylamino optionally N-substituted by one or two groups selected from C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4 alkyl, phenyl or phenyl C1-4 alkyl groups or optionally N-disubstituted by C4-5 polymethylene; and Z is a group of formula (a), (b) or (c) <IMAGE> (a) <IMAGE> (b) <IMAGE> (c) wherein n is 2 or 3; p is 1 or 2; q is 1 to 3; r is 1 to 3; and R3 or R4 is C1-7 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-2 alkyl or C2-7 alkylenyl-C1-4 alkyl; having 5-HT M-receptor antagonist activity, a process for their preparation and their use as pharmaceuticals. |
