| 摘要 |
PURPOSE:To reduce recemization and obtain the titled antibiotic substance useful as an antimicrobial agent in a few steps, by reacting a specific adenine derivative as a starting material with an alanine derivative and treating the resultant product with an acid. CONSTITUTION:2-Chloro-2-(2',3'-O-isopropylidene-5'-O-sulfamoyl-beta-D- -ribofuranoo xyl)adenine expressed by formula I is reacted with a compound expressed by formula II (Boc is tert-butyloxycarbonyl), e.g. tert-butyloxycarbonyl-L-alanine, etc., in the presence of a proton abstracting agent, e.g. cesium carbonate, nor mally in a solvent, e.g. DMF, preferably at -78 - +100 deg.C for 1-20hr to give a compound expressed by formula III, which is then treated with an acid, e.g. trifluoroacetic acid, to afford the aimed compound expressed by formula IV.
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