发明名称 |
Transdermal drug delivery devices with amine-resistant silicone adhesives |
摘要 |
This invention relates to an improved transdermal drug delivery device for the controlled transdermal delivery of amino-functional drugs. The improvement resides in providing the device with a silicone pressure-sensitive adhesive layer which has been chemically treated to reduce the silicon-bonded hydroxyl content of the pressure-sensitive adhesive composition to render the adhesive layer resistant to loss of tack and preserve the instant adherence of the device to the skin of a wearer during storage and while the device is being worn. Preferably, the composition used comprises a silicon-bonded hydroxyl radical containing resinous copolymer of R3SiO1/2 units and SiO4/2 units and a polydiorganosiloxane which have been chemically treated with R3SiO1/2 units where R is preferably a hydrocarbon radical such as a methyl group to reduce the silicon-bonded hydroxyl content of the adhesive and thereby its sensitivity to amino-functional drugs.
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申请公布号 |
US4655767(A) |
申请公布日期 |
1987.04.07 |
申请号 |
US19850780505 |
申请日期 |
1985.09.26 |
申请人 |
DOW CORNING CORPORATION |
发明人 |
WOODARD, JOHN T.;METEVIA, VIRGIL L. |
分类号 |
A61K9/70;(IPC1-7):A61F13/02;A61J1/00 |
主分类号 |
A61K9/70 |
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