| 摘要 |
NEW MATERIAL:The compound of formula I(R1 is lower alkyl; R2 is H or NH2; X is halogen) and its salt. EXAMPLE:8-Fluoro-9-(1, 4-diazabicyclo[4, 3, 0]nonan-1-yl)-2-methyl-1,2-dihydro-6- oxopyrrolo[3,2,1-ij]quinoline-5-carboxylic acid. USE:An antibacterial agent. PREPARATION:For example, the compound of formula II(X' is halogen) {e.g. 8,9-difluoro-2-methyl-1,2-dihydro-6-oxopyrrolo[3,2,1-ij]quinoline-5-ca rboxylic acid} is made to react with preferably 1-5 times mol of 1,4-diazabicyclo[4,3,0]nonane of formula II in a solvent (preferably N-methylpyrrolidone, etc.) under 1-10 atm at 100-200 deg.C for 0.5-20hr. |
