发明名称 |
COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT |
摘要 |
The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective amount of an EGFR kinase inhibitor and an IGFlR inhibitor compound of Formula I combination, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The invention also encompasses a pharmaceutical composition that is comprised of an EGFR kinase inhibitor and IGFlR inhibitor compound of Formula I combination with a pharmaceutically acceptable carrier. The IGFlR inhibitor is represented by Formula I. wherein X<SUB>1</SUB> X<SUB>2</SUB>, X<SUB>3</SUB>, X<SUB>4</SUB>, X<SUB>5</SUB>, X<SUB>6</SUB>, X<SUB>7</SUB>, R<SUP>1</SUP>, and Q<SUP>1</SUP> are defined herein. |
申请公布号 |
WO2007075554(A3) |
申请公布日期 |
2007.09.20 |
申请号 |
WO2006US48222 |
申请日期 |
2006.12.18 |
申请人 |
OSI PHARMACEUTICALS, INC.;JI, QUN-SHENG;ARNOLD, LEE, D.;MULVIHILL, MARK, JOSEPH |
发明人 |
JI, QUN-SHENG;ARNOLD, LEE, D.;MULVIHILL, MARK, JOSEPH |
分类号 |
A61K45/06;A61K31/4985;A61K31/519;A61K31/53;A61P35/00;A61P35/04 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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